论文部分内容阅读
目的：基本消灭丝虫病后如何巩固丝虫病防治成果，观察丝虫病的消长规律，达到消灭丝虫病。方法：从１９７７—１９９５年４７个原流行县开展病原学、媒介和血清学纵、横向监测。结果：贵州省４７个县连续１２—１８年的监测结果表明，已连续４—１８年未发现微丝蚴阳性者，６—１６年蚊媒监测无人体幼丝虫感染，血清学（ＩＦＡＴ）监测，平均人群抗体阳性率从１９８５年的２３．５％降至１９９２年的５．７％，与非流行区人群水平相似。分析认为，基本消灭丝虫病后只需对薄弱环节及时补课，不必再进行大面积查治，一般残存的马来和班氏微丝蚴血症者分别于１—３年及３—１４年转阴，达到消灭丝虫病。基本消灭丝虫病后的监测时间，马来丝虫病地区５年即可，而班氏丝虫病地区以１０年以上为宜。作者将单克隆抗体和ＤＮＡ探针聚合酶链反应（ＰＣＲ）技术分别用于现场血清学和媒介监测，由于方法准确，敏感性和特异性较强，具有实用价值。结论：１９９５年经省内、外丝虫病防治专家组审评，贵州省已实现全省消灭丝虫病。
Objective: To basically eliminate filariasis after how to consolidate the prevention and treatment of filariasis, observe the growth and decline of filariasis law, to eliminate filariasis. Methods: From 1977 to 1995, the 47 endemic counties carried out longitudinal and transverse monitoring of etiology, media and serology. Results: The monitoring results of 12 to 18 consecutive years in 47 counties of Guizhou Province showed that no micromeLia were found in 4 to 18 consecutive years, no mosquito larvae were detected in mosquitoes from 6 to 16 years, and serological (IFAT) Monitoring, the average population antibody positive rate from 23.5% in 1985 dropped to 5.7% in 1992, and non-endemic populations similar levels. Analysis shows that after the basic elimination of filariasis simply make up the weak links in a timely manner, no longer conduct a large area of investigation, the general survival of the remaining Malay and Bancrofti microfilaria in 1 - 3 years and 3 - 14 years Negative, to eliminate filariasis. After the basic elimination of filariasis monitoring time, Malay filariasis area can be 5 years, and Bancroftian filariasis areas more than 10 years is appropriate. The authors used monoclonal antibodies and DNA probe polymerase chain reaction (PCR) techniques for on-site serology and vector monitoring, respectively, and are of practical value because of their accuracy, sensitivity and specificity. Conclusion: In 1995, the province, outside the filariasis control expert group review, Guizhou province has achieved the province eliminate filariasis.