病原菌对宿主致病是病原菌与宿主复杂相互作用的结果。病原菌与宿主相互作用可造成宿主在细胞、组织及器官不同水平的损伤。病原菌对宿主的致病性及毒力,一方面在于病原菌,另一方面在于宿主因素以及宿主与病原菌的相互作用。病原菌-宿主在细胞水平的相互作用是病原菌感染致病的重要环节。结合本课题组对猪链球菌的研究,从黏附与定殖、侵袭、逃避与扩散等方面概述病原菌逃避宿主细胞防御的机制。 Pathogenesis of the host pathogen is the result of complex interactions between the pathogen and the host. Pathogens and host interaction can cause the host cells, tissues and organs at different levels of damage. Pathogenicity and virulence of pathogens to the host, on the one hand is the pathogen, on the other hand, the host factor and host and pathogenic bacteria interaction. Pathogen - the host cell-level interactions are important pathogenic pathogens infection. Combined with our research on Streptococcus suis, this paper summarizes the mechanism that pathogens evade host cell defense from aspects of adhesion and colonization, invasion, escape and spread.