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人乳头状瘤病毒(HPV)阳性的口咽癌发病机制尚不清楚。该文作者通过分析不同样本小干扰RNA的表达情况,以期获得有价值的信息。纳入研究的26例口咽癌患者中,16例HPV阳性,共鉴别出25种miRNA印迹。小干扰RNA与Wnt和PI3K信号通路中细胞黏附、细胞极性及细胞结构的调控明显相关。结论:该研究结果证实,HPV阳性与口咽癌患者明显相关。进一步阐明其作用机制,可为临床治疗
The pathogenesis of human papillomavirus (HPV) -positive oropharyngeal carcinoma is unclear. The author through the analysis of different samples of small interfering RNA expression, in order to obtain valuable information. Of the 26 patients with oropharyngeal cancer included in the study, 16 were HPV positive and 25 were identified as miRNAs. Small interfering RNA is significantly associated with cell adhesion, cell polarity and cell structure regulation in Wnt and PI3K signaling pathways. Conclusions: The results of this study confirm that HPV-positive is significantly associated with oropharyngeal cancer. To further clarify its mechanism of action, for clinical treatment