鳞癌占口腔颌面部恶性肿瘤的90%,尽管在肿瘤学和手术学方面取得了巨大的进展,但是头颈部鳞癌的复发率和病死率仍然居高不下。近年来随着对肿瘤研究的不断发展,研究者发现某些肿瘤细胞与干细胞具有相似的生长调控机制,肿瘤细胞中也存在等级现象和异质性,由此提出了肿瘤干细胞的概 Squamous cell carcinoma accounts for 90% of oral and maxillofacial malignancies. Despite great advances in oncology and surgery, the recurrence rate and mortality of head and neck squamous cell carcinoma remain high. In recent years, with the continuous development of cancer research, the researchers found that some tumor cells and stem cells have a similar mechanism of growth and regulation, there are also hierarchical phenomenon and heterogeneity in tumor cells, thus presenting the concept of cancer stem cells