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目的比较门冬胰岛素50注射液与地特胰岛素联合口服药治疗初发2型糖尿病患者的临床疗效。方法连续收集2015年8月至2016年3月于河北省人民医院就诊的初发2型糖尿病患者60例,随机分为门冬胰岛素50注射液组(预混组)与地特胰岛素联合口服药治疗组(地特组),各30例,共干预12周。观察两组患者干预前后空腹血糖(FPG)、餐后2h血糖(2hPG)和糖化血红蛋白(HbA1c)的变化及低血糖的发生情况。结果预混组与地特组的基线临床特征无差异。干预12周后,预混组2hPG较地特组下降明显(8.54±1.37 vs.7.52±1.58),差异有统计学意义(P=0.009)。在干预12周时,预混组2hPG和HbA1c的水平均低于地特组(P<0.05)。两组在低血糖发生率上无差异(P>0.05)。结论在初发2型糖尿病患者中,门冬胰岛素50注射液与地特胰岛素联合口服药均可有效降低糖化血红蛋白,门冬胰岛素50注射液控制餐后血糖优于地特胰岛素联合口服药。
Objective To compare the clinical efficacy of insulin aspart 50 injection combined with detemir insulin in the treatment of newly diagnosed type 2 diabetic patients. Methods Sixty patients with newly diagnosed type 2 diabetes who were treated in Hebei Provincial People’s Hospital from August 2015 to March 2016 were randomly divided into insulin aspart 50 injection group (pre-mixed group) and insulin detemir combined oral drug Treatment group (special group), each 30 cases, a total of 12 weeks intervention. The changes of fasting blood glucose (FPG), 2h postprandial blood glucose (2hPG) and HbA1c and the incidence of hypoglycemia in both groups before and after intervention were observed. Results There was no difference in the baseline clinical characteristics between the premixed group and the special group. After intervention for 12 weeks, 2hPG in pre-mixed group decreased significantly (8.54 ± 1.37 vs.7.52 ± 1.58) compared with the control group, the difference was statistically significant (P = 0.009). At 12 weeks of intervention, the levels of 2hPG and HbA1c in the premixed group were lower than those in the geotextilet group (P <0.05). There was no difference in the incidence of hypoglycemia between the two groups (P> 0.05). Conclusions In patients with newly diagnosed type 2 diabetes, insulin aspart 50 injection combined with insulin detemir can reduce HbA1c significantly, and insulin aspart 50 injection can control postprandial blood glucose better than insulin detemir plus oral medication.