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目的 探讨焦炉工外暴露等级与尿中 1-羟基芘浓度之间的关系。方法 以某焦化厂 30 5名生产工人和 30名非接触者为调查对象 ,统一收集工作周末班后 6h尿 ,并收集个人信息。根据工人的工作岗位将调查对象分为炉顶、炉侧、炉底和对照 4个外暴露等级。采用碱水解 -高效液相色谱法测定尿中1-羟基芘浓度。使用协方差分析和多元线性回归分析暴露等级、吸烟和饮酒等情况对尿中 1-羟基芘浓度的影响。结果 尿中 1-羟基芘的浓度呈炉顶 >炉侧 >炉底 >对照的趋势 ,与外暴露等级之间呈显著相关(Spearman相关系数为 0 5 35 ,P <0 0 1) ;在同样外暴露条件下 ,吸烟量显著影响尿中 1-羟基芘的水平(P <0 0 5 ) ;未发现饮酒对尿中 1-羟基芘水平的显著影响。结论 焦炉工尿中 1-羟基芘水平与外暴露等级之间存在良好的剂量 -效应关系 ,可反映多环芳烃暴露个体的内剂量水平
Objective To investigate the relationship between the level of exposure to coke oven workers and the concentration of urinary 1-hydroxypyrene. Methods A total of 305 production workers and 30 non-contact workers in a coking plant were investigated. Urine was collected 6 hours after work weekend classes and personal information was collected. According to the workers’ jobs, the survey subjects were divided into four levels of exposure, including the top, the furnace side, the bottom and the control. Urinary 1-hydroxypyrene concentration was determined by alkaline hydrolysis-high performance liquid chromatography. Covariance analysis and multivariate linear regression analysis of exposure levels, smoking and drinking on the urinary 1-hydroxypyrene concentration. Results The urinary concentration of 1-hydroxypyrene tended to increase from top to bottom of furnace to bottom of furnace. The Spearman correlation coefficient was significantly correlated with the level of external exposure (Spearman correlation coefficient: 0.0535; P <0.01) Under external exposure conditions, smoking significantly affected the level of urinary 1-hydroxypyrene (P <0.05); no significant effect of alcohol consumption on urinary 1-hydroxypyrene levels was found. Conclusion There is a good dose-response relationship between the level of urinary 1-hydroxypyrene and the level of external exposure in coke oven workers, which can reflect the internal dose level of PAH exposed individuals