目的　探索Hp感染与十二指肠溃疡复发及再出血的关系。方法　对 5 8例已治愈并清除Hp感染的十二指肠溃疡患者进行跟踪 ,症状复发者及时做胃镜检查和Hp检测。结果　 2年内十二指肠溃疡复发率 77 6% (45 /5 8例 ) ,其中Hp+ 86 7% (3 9/45例 ) ,Hp-13 3 % (6/45例 ) ,P <0 0 1;溃疡合并再出血 18例 ,占 40 % ,其中Hp+ 94 4% ,Hp-5 6% ,P <0 0 1。结论　Hp感染是十二指肠溃疡复发及再出血的重要因素。 Objective To explore the relationship between Hp infection and recurrence and rebleeding of duodenal ulcer. Methods Fifty-eight patients with duodenal ulcer who had been cured and cleared of Hp infection were followed up. Gastroscopy and Hp examination were performed in time. Results The recurrence rate of duodenal ulcer in two years was 77.6% (45/58), of which Hp + 86 was 7% (39/45), Hp-13 3% (6/45), P <0 0 1; ulcer combined rebleeding in 18 cases, accounting for 40%, of which Hp + 94 4%, Hp-5 6%, P <0 01. Conclusion Hp infection is an important factor in the recurrence and rebleeding of duodenal ulcer.