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目的:分析胰岛素或磺脲类药物联合二甲双胍治疗初发Ⅱ型糖尿病患者的临床疗效。方法:回顾性分析2014年1月-2015年6月本院诊治的50例初发Ⅱ型糖尿病患者临床资料,按照治疗时不同治疗方案分为两组,对照组予磺脲类药物联合二甲双胍治疗,研究组予甘精胰岛素联合二甲双胍治疗,对比两组临床具体治疗情况。结果:血糖指标指标均较治疗前明显改善,但是研究组改善幅度更显著,优于对照组;且研究组并发症4.54%低于对照组24.07%,比较差异具有统计学意义(P<0.05)。结论:胰岛素联合二甲双胍治疗初发Ⅱ型糖尿病效果优于磺脲类药物联合二甲双胍,同时可改善患者胰岛功能,降低糖尿病并发症。
Objective: To analyze the clinical efficacy of insulin or sulfonylurea combined with metformin in the treatment of newly diagnosed type 2 diabetic patients. Methods: The clinical data of 50 patients with newly diagnosed type 2 diabetes mellitus diagnosed and treated in our hospital from January 2014 to June 2015 were retrospectively analyzed. The patients were divided into two groups according to different treatment regimens. The control group was treated with sulfonylureas and metformin , The study group to insulin glargine and metformin treatment, the two groups compared to the specific clinical treatment. Results: The indexes of blood glucose were significantly improved compared with before treatment, but the improvement rate of the study group was more significant than that of the control group. The complication rate of the study group was 4.54% lower than that of the control group (24.07%), with significant difference (P <0.05) . Conclusion: The combination of insulin and metformin in the treatment of primary type Ⅱ diabetes mellitus is superior to sulfonylureas in combination with metformin, meanwhile it can improve the islet function and reduce the complication of diabetes mellitus.