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本文报道我们自1985年7月至今,共收治12例晚期神经母细胞瘤,其中Ⅲ期4例,Ⅳ期8例。年龄14个月～8岁,中位年龄5岁。采用以顺铂十V_(p1(?))为基础的强烈联合化疗、手木、放疗等综合措施后,除1例在术前因化疗并发症死亡外,存活11例,经多次骨髓检查、腹部B型超声波或CT、尿VMA检查,均恢复正常,且生存质量良好,最长随访期已达3年以上,持续完全缓解期在4～40个月间,中位随访期为6个月,已达国际报道的Ⅳ期神经母细胞瘤治疗水平。本文并对以顺铂十V_(p1(?))为基础的联合化疗方案的毒性及处理方法,作了简要讨论。
This article reports that we have treated 12 patients with advanced neuroblastoma since July 1985, of which 4 were in stage Ⅲ and 8 in stage Ⅳ. Aged 14 months to 8 years old, the median age of 5 years old. After comprehensive combination chemotherapy, hand-wood and radiotherapy based on cisplatin ten V (p1 (?)), 11 patients survived due to chemotherapy complications before surgery, and after multiple bone marrow examinations , Abdominal B type ultrasound or CT, urine VMA examination, returned to normal, and good quality of life, the longest follow-up period has reached more than 3 years, sustained complete remission in 4 to 40 months, the median follow-up period of 6 Month, has reached the international coverage of stage Ⅳ neuroblastoma treatment. This article and the cisplatin ten V_ (p1 (?)) Based on the combination of chemotherapy toxicity and treatment, made a brief discussion.