螺环氧化吲哚结构是很多药理活性分子的核心骨架,其结构复杂且在合成过程中立体选择性难以控制,因此含有该骨架的化合物是药物和有机化学家关注的热点。按吲哚C(3)位上构建的三元螺环、四元螺环、五元螺环和六元螺环进行分类,介绍近5年来有机小分子不对称催化构建螺环氧化吲哚化合物的研究进展,以期为该类化合物的合成提供参考价值。 Spiro epoxidation of indole structure is the core skeleton of many pharmacologically active molecules, its structure is complex and the stereoselectivity in the synthesis process is difficult to control, so the compound containing the skeleton is a hot topic of concern for pharmaceutical and organic chemists. According to the three-position spiro, four-spiro, five-spiro and six-spiro spindles constructed on the indole C (3) position, the asymmetric catalysis of spiro epoxidation of small organic molecules The research progress of the compounds, with a view to provide reference value for the synthesis of these compounds.