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目的：为比较肝素经静脉和肺两种途径给药的血药浓度变化特点。方法：给慢性阻塞性肺病（ＣＯＰＤ）患者经静脉及射流雾化定时予肝素１００ｍｇ·ｄ－１，共７ｄ。首次给药后定时查肝素血药浓度。结果：发现肝素确可经肺途径入血，首次雾化后１．５ｈ血药浓度达高峰，以后迅速降低，第７天再度升高，停药３ｄ血中仍有低浓度肝素存在。静脉给药者血药浓度高峰亦出现于首次给药后１．５ｈ，但峰值明显高于经肺给药者（Ｐ＜０．０１），以后渐降低，２４ｈ已大部排泄。第７天血中虽可检出微量肝素，但明显低于经肺给药者（Ｐ＜０．０１）。结论：肝素静脉给药血中药物浓度高，维持时间短。而经肺给药可长时间、低水平的维持血中肝素浓度，停药７２ｈ血中仍可检出微量肝素
Objective: To compare the changes of plasma concentration of heparin administered by both venous and pulmonary routes. Methods: Chronic obstructive pulmonary disease (COPD) patients were given heparin 100mg · d-1 by atomization and jet atomization for 7 days. The first time after administration of heparin plasma concentration. Results: Heparin was found to enter the bloodstream via the pulmonary route. After 1.5 hours of initial nebulization, the plasma concentration peaked and then decreased rapidly. On the 7th day, the heparin level increased again. There was still a low concentration of heparin in 3d blood. The peak plasma concentration of intravenous administration also appeared 1.5h after the first administration, but the peak was significantly higher than that of the pulmonary administration (P <0.01), then gradually decreased, most of 24h excretion. Although heparin was detected on the 7th day in the blood, it was significantly lower than those on the lung (P <0.01). Conclusion: Heparin intravenous drug concentration in the blood, maintaining a short time. The lung administration can be a long time, low levels of blood to maintain heparin concentration, withdrawal 72h blood can still be detected in trace amounts of heparin