近年来的研究表明用蒿甲醚或蒿琥酯钠盐经皮肤给药治疗伯氏疟原虫小鼠或感染食蟹猴疟原虫的猕猴获得较口服这些药物为好的疗效。对羧基苄醚(artelinic acid)是青蒿素的衍生物,其钠盐具有与蒿琥酯钠盐相同的抗疟作用,但其最大的优点是在水溶液中不易水解。故作者用对羧基苄醚经皮肤给药治疗感染伯氏疟原虫的小鼠。经皮肤给药的对羧基苄醚的制剂为:3g乙基纤维素完全溶 Recent studies have shown that transdermal administration of artemether or artesunate sodium salt to P. berghei mice or to cynomolgous macaques infects cynomolgous macaques is superior to oral administration of these drugs. Artelinic acid is a derivative of artemisinin whose sodium salt has the same anti-malarial effect as artesunate sodium salt, but its greatest advantage is that it is not easily hydrolyzed in aqueous solution. Therefore, the authors transdermally administered p-carboxybenzyl ether to mice infected with P. berghei. The formulations of transdermally administered p-carboxybenzyl ether are: 3 g of ethyl cellulose is completely dissolved