近来研究表明,维生素K具有抗炎、干扰电子转运、和巯基结合干扰细胞的基本功能等作用。本文报道维生素K体外对人血小板聚集功能的影响。实验用Born氏法测定血小板聚集性。所得结果表明,维生素K_3、K_4和K_7明显抑制ADP、胶原、凝血酶和花生四烯酸诱导的PRP和洗血小板聚集,存在剂量依赖关系,IC50为16.2—45.7μM,而对Ca~(2+) Recent studies have shown that vitamin K has anti-inflammatory, interferes with electron transport, and sulfhydryl binding interfere with the basic functions of cells and so on. This article reports the effect of vitamin K on human platelet aggregation in vitro. Platelet aggregation was measured by Born’s method. The results showed that vitamin K_3, K_4 and K_7 significantly inhibited ADP, collagen, thrombin and arachidonic acid induced PRP and platelet aggregation in a dose-dependent manner with IC50 of 16.2-45.7μM, while Ca 2+ )