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探讨肠易激综合征(irritablebowelsyndrome,IBS)患者肠粘膜肥大细胞 (mastcell,MC)计数有无变化 ,以及它在IBS中的可能作用和临床意义。粘膜标本取自 15名正常人和 2 8例IBS患者回肠末端、回盲部 (ileocecaljunction ,ICJ)、升结肠、乙状结肠 ,应用特殊组化染色法对MC进行染色 ,并应用彩色病理图像分析软件进行分析 ;电镜观察MC的结构及其毗邻结构。结果显示 ,IBS患者回肠末端、回盲部、升结肠MC明显增多 (P <0 0 1) ,MC显著变异 ;并可观察到MC与无髓神经末梢及浆细胞等内分泌细胞毗邻或密切接触。研究表明 ,MC在IBS的病理生理机制中可能起关键性的作用 ,MC活性与IBS内脏感觉及动力变化相关联 ,MC稳定剂或MC产物拮抗剂对IBS可能具有治疗作用。
To investigate the change of count of mastcell (MC) in patients with irritable bowel syndrome (IBS) and its possible role in IBS and its clinical significance. Mucosa specimens from 15 normal subjects and 28 patients with IBS ileocecal ileocecal junction (ICJ), ascending colon, sigmoid colon, stained with a special histochemical staining of MC, and color pathological image analysis software Analysis; electron microscopy MC structure and its adjacent structure. The results showed that patients with IBS had significantly increased ileum, ileocecal region, ascending colon MC (P <0.01), significant variation of MC, and adjacent or close contact between MC and non-myelinated nerve endings and endocrine cells such as plasma cells. Studies have shown that MC may play a key role in the pathophysiological mechanism of IBS, MC activity is associated with visceral sensation and motility in IBS, and MC stabilizer or MC antagonist may have a therapeutic effect on IBS.