卡马西平(CBZ)系一种用于治疗部分复杂性癫痫发作和大发作的抗痉剂。作者报告一例由于合并红霉素而导致CBZ 中毒的病例。女性,41岁,有长期的癫痫病史。2年来一直接受CBZ 和苯巴比妥钠治疗,并经常测定血浆药物浓度。入院7个月中,她服CBZ 400mg3次/日和苯巴比妥钠100mg4次/日,血浆CBZ 浓度9.3～13.3mg/L(治疗量血浓度应为4—12mg/L)。入院前19天,血浆CBZ 浓度为13.3mg/L,血浆苯巴比妥钠浓度17.4mg/L,2天后,患者意外地跌倒致右锁骨骨折和右额撕裂伤,入院前10天伤口感染,而口服红霉素500mg4次/日,治疗后3天,出现眩晕,其后2天又感觉视力模糊和平衡失调,治疗后7天出现恶心和呕吐, Carbamazepine (CBZ) is an antispasmodic agent used to treat partially complex seizures and major attacks. The authors report a case of CBZ intoxication due to erythromycin. Female, 41 years old, has a long history of epilepsy. 2 years have been treated with CBZ and phenobarbital sodium, and often measured plasma drug concentrations. In the 7 months of admission, she took CBZ 400mg 3 times a day and phenobarbital 100mg 4 times a day, plasma CBZ concentration 9.3 ~ 13.3mg / L (the therapeutic blood concentration should be 4-12mg / L). Nineteen days prior to admission, plasma CBZ concentration was 13.3 mg / L and plasma phenobarbital sodium concentration was 17.4 mg / L. Two days later, the patient accidentally fell to the right clavicle fracture and right front laceration, and wound infection ten days prior to admission , While oral erythromycin 500 mg 4 times / day, 3 days after treatment, dizziness, then 2 days and blurred vision and balance disorders, 7 days after treatment nausea and vomiting,