Liver diseases are an important and largely neglected health issue in low and middle income countries,which carry the highest burden.In this Topic Highlight,experts review hepatitis B and E,alcoholic liver disease,hepatic diseases in human immunodeficiency virus-infected individuals,hepatocellular carcinoma.Numerous gaps in our knowledge that need to be filled are outlined and feasible solutions to the several problems related to diagnosis and management of liver diseases in developing countries are suggested. Liver diseases are an important and largely neglected health issue in low and middle income countries, which carry the highest burden. Experts review hepatitis B and E, alcoholic liver disease, hepatic diseases in human immunodeficiency virus-infected individuals, hepatocellular Numerous gaps in our knowledge that need to be filled are outlined and feasible solutions to the several problems related to diagnosis and management of liver diseases in developing countries are suggested.