人类胎盘碱性磷酸酶(HPLAP)是一种膜结合糖蛋白,其活性形式为由两个亚基构成的二聚体。虽然其生物学作用尚未阐明,但鉴于它能在肿瘤细胞异位合成,在癌症病人血清中可被检出,所以它已成为检测某些肿瘤的一顶有用的指标。HPLAP表现出高度的遗传多型性;已报告了三种常见的等位基因(PI~s、PI~f与PI~i及15种以上的罕见等位基因型。由于此酶是二聚体,所以三个常见的等位基因可产生六种常见的表现型:SS、FS、 Human placental alkaline phosphatase (HPLAP) is a membrane-bound glycoprotein whose active form is a dimer composed of two subunits. Although its biological role has not yet been elucidated, it has become a useful indicator for the detection of certain tumors, given that it can be detected in the serum of cancer patients given that it can be produced heterotopic in tumor cells. HPLAPs exhibit a high degree of genetic polymorphism; three common alleles (PI-s, PI-f, PI-i, and rare alleles of more than 15) have been reported. Since this enzyme is a dimer , So three common alleles can produce six common phenotype: SS, FS,