临床药动学分布容积二室模型能准确地反映许多药物的分布情况,尤其适用于描述静脉给药后的药动学。在给药初期,药物在灌注良好的器官(心脏、肺、脑及其他脏器)中的浓度较高,经一定时间后,这些器官与身体其他部分间的药物浓度发生重分布,使前者的药物浓度下降。比如,抗心律失常药开始在心肌中的浓度较高,但不久就降至无效浓度。药物初始高浓度是药物分布于中央室的结果。 Clinical pharmacokinetic distribution volume two-compartment model can accurately reflect the distribution of many drugs, especially for describing the pharmacokinetics after intravenous administration. At the initial administration, the drug is highly concentrated in well-perfused organs (heart, lung, brain, and other organs). After a certain period of time, drug concentrations in these organs and other parts of the body are redistributed, Drug concentration decreased. For example, antiarrhythmic drugs begin to have higher concentrations in the myocardium but soon fall to ineffective concentrations. The initial high drug concentration is the result of drug distribution in the central chamber.