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目的 :探讨丹参抗大鼠乙醇性胃粘膜损伤的作用及机制。方法 :采用 10 0 %乙醇复制大鼠乙醇性胃粘膜损伤模型 ,用放射免疫法测定胃粘膜内前列腺素 E2 (PGE2 )、前列腺素 I2 (PGI2 )的含量 ,用浓盐法测定胃粘膜内DNA的含量。结果 :丹参组的胃粘膜损伤指数低于对照组 (P <0 .0 1) ;胃粘膜内 PGE2 、PGI2 含量高于对照组 (均 P<0 .0 1) ;DNA含量高于对照组 (P <0 .0 1)。结论 :丹参促进胃粘膜细胞 DNA的合成和胃粘膜细胞的增殖 ,使PGE2 、PGI2 含量增加 ,进而促进了胃粘液的分泌。
Objective: To explore the effect and mechanism of salvia miltiorrhiza on ethanol-induced gastric mucosal injury in rats. METHODS: A rat model of ethanolic gastric mucosal injury was replicated by 10% ethanol. The content of prostaglandin E2 (PGE2) and prostaglandin I2 (PGI2) in gastric mucosa was measured by radioimmunoassay. The gastric mucosal DNA was measured by concentrated salt method. The content. Results: The gastric mucosal injury index of Danshen group was lower than that of the control group (P < 0.01). The content of PGE2 and PGI2 in gastric mucosa was higher than that of the control group (all P <0.01); the DNA content was higher than that of the control group ( P <0. 0 1). Conclusion: Salvia miltiorrhiza can promote the synthesis of DNA in gastric mucosal cells and the proliferation of gastric mucosal cells, increase the content of PGE2 and PGI2, and promote the secretion of gastric mucus.