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目的 :探讨酚妥拉明和多巴胺治疗难治性哮喘的临床疗效。方法 :每次以酚妥拉明 ( 0 .5～ 1 )mg/kg ,多巴胺 ( 0 .2 5～ 0 .5)mg/kg加入 1 0 %葡萄糖溶液 ( 1 0 0～ 1 50 )ml中用微泵控制滴速 ,以 5μg·kg- 1·min- 1静滴 ,连用3d ,观察疗效。结果 :用药后 1 2～ 2 4h ,气急渐平 ,心率减慢 ,紫绀消失 ,哮鸣音减少 ,血气基本恢复正常 ,总有效率达 93.3% ,未发现明显副作用。结论 :在抗炎、吸氧、解痉、纠酸、补液的基础上 ,加用酚妥拉明和多巴胺治疗难治性哮喘有明显疗效。
Objective: To investigate the clinical efficacy of phentolamine and dopamine in the treatment of refractory asthma. Methods: Each time, 10% glucose solution (100 ~ 150) ml was added into the solution of phentolamine (0.5-1 mg / kg, dopamine 0.5-2.5 mg / kg) With the micro-pump control drip rate, intravenous infusion of 5μg · kg-1 · min-1, even 3d, observe the effect. Results: After 12 ~ 24 hours after treatment, the rate of acute and flatten, the heart rate slowed down, cyanosis disappeared, wheeze decreased, blood gas returned to normal, with a total effective rate of 93.3%, no significant side effects were found. Conclusion: In the anti-inflammatory, oxygen, spasm, acid correction, rehydration, based on the addition of phentolamine and dopamine treatment of refractory asthma with significant effect.