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目的对成人癫痫采取托吡酯与丙戊酸钠治疗疗效随机对照研究进行Meta分析,以期为临床治疗提供借鉴。方法通过文献检索的方式检索万方、知网等数据库有关于国内成人癫痫采取托吡酯与丙戊酸钠治疗疗效随机对照研究,并进行Meta分析。结果共计10个文献研究纳入分析,成人癫痫患者1582例,托吡酯与丙戊酸钠治疗有效性对比可知合并RR值=1.15(1.06,1.25),差异有统计学意义(P<0.05);不良反应对比分析可知,头晕合并RR值差异无统计学意义(P>0.05),而嗜睡与体重下降合并RR值则皆差异有统计学意义(P<0.05)。结论成人癫痫患者采取托吡酯治疗总体疗效更优,不良反应中嗜睡发生率低,但极易引发体重下降,需加强重视。
Objective To investigate the effects of topiramate and valproate on adult epilepsy in a meta-analysis of the results of randomized controlled trials in order to provide reference for clinical treatment. Methods To search the databases of Wanfang, Zhilian and other databases by means of literature search, a randomized controlled study on the efficacy of topiramate and valproate in domestic adult epilepsy was conducted and analyzed by Meta-analysis. Results A total of 10 literature studies were included in the analysis. Among 1582 adults with epilepsy, the RR of RRT was 1.15 (1.06, 1.25), the difference was statistically significant (P <0.05); Adverse reactions Comparative analysis showed that there was no significant difference in drowsiness RR value (P> 0.05), while drowsiness and weight loss combined with RR value were significantly different (P <0.05). Conclusion The overall efficacy of topiramate treatment in adults with epilepsy is better, and the incidence of lethargy in adverse reactions is low, but easily lead to weight loss, need to pay more attention.