新形隐球菌性脑膜炎在过去无特效治疗,曾作多种尝试如发热疗法、紫外线疗法、X 线治疗、重金属、磺胺类、抗菌素、免疫血清等等。数百种化学药物曾被在试管中试验以抑制新形隐球菌。Mosberg 氏等(1950)综合至1949年止全部所报告的病例,在总结25种治疗方法时认为全部无效。Carton 氏(1952)(2)综合约200例中枢神经系统隐球菌病时,指出在此组病例中所谓生存的14例,只有一例可称为治愈;此 Cryptococcus neoformans meningitis in the past no special treatment, there have been a variety of attempts such as fever, UV therapy, X-ray therapy, heavy metals, sulfonamides, antibiotics, immune serum and so on. Hundreds of chemicals have been tested in tubes to inhibit C. neoformans. Mosberg et al. (1950) integrated all reported cases until 1949, and concluded that all 25 treatments were totally ineffective. Carton’s (1952) (2) combined of about 200 cases of central nervous system cryptococcosis, pointed out that in this group of patients so-called survival in 14 cases, only one case can be called cure; this