AIM:To formulate a noninvasive index predictive of se-verity of liver f ibrosis and activity in chronic hepatitis C.METHODS:This cross sectional study was conducted on polymerase chain reaction positive,treatment nave patients.Fibrosis was staged on a f ive point scale from F0-F4 and activity was graded on a four point scale from A0-A3,according to the METAVIR system.Patients were divided into two overall severity groups,minimal disease(< F2 and < A2)and signif icant disease(≥ F2 or ≥ A2).Eleven markers were measured in blood.Sta-tistically,the primary outcome variable was identif ica-tion of minimal and signif icant overall disease.Indices were formulated using β regression values of different combinations of nine statistically significant factors.Diagnostic performance of these indices was assessed through receiver-operating characteristic curve analysis.RESULTS:A total of 98 patients were included and of these 46 had an overall clinically significant disease.Our f inal six marker index,Liverscore for Hepatitis C,consisted of age,alanine transaminase,gamma-gluta-myl transpeptidase,apolipoprotein A-1,alpha-2 macro-globulin and hyaluronic acid.The area under the curve was found to be 0.813.On a 0-1 scale,negative predic-tive value at a cutoff level of ≤ 0.40 was 83%,while positive predictive value at ≥ 0.80 remained 89%.Al-together,61% of the patients had these discriminative scores.CONCLUSION:This index is discriminative of minimal and significant overall liver disease in a majority of chronic hepatitis C patients and can help in clinical de-cision making. AIM: To formulate a noninvasive index predictive of se-verity of liver f ibrosis and activity in chronic hepatitis C. METHHODS: This cross sectional study was conducted on polymerase chain reaction positive, treatment nave patients. Fibrosis was staged on af ive point scale from F0-F4 and activity was graded on a four point scale from A0-A3, according to the METAVIR system. Patients were divided into two overall severity groups, minimal disease ( F2 or ≥ A2). Eleven markers were measured in blood. Sta- tistically, the primary outcome variable was identified ica-tion of minimal and signif icant overall disease. Indices were formulated using β regression values ​​of different combinations of nine exhibiting significant factors. Diagnostic performance of these indices was assessed through receiver-operating characteristic curve analysis. RESULTS: A total of 98 patients were included and of these 46 had an overall clinically significant disease. Our f inal six m arker index, Liverscore for Hepatitis C, consisted of age, alanine transaminase, gamma-gluta-myl transpeptidase, apolipoprotein A-1, alpha-2 macro- globulin and hyaluronic acid. 0-1 scale, negative predic-tive value at a cutoff level of ≤ 0.40 was 83%, while positive predictive value at ≥ 0.80 remained 89% .Al-together, 61% of the patients had these discriminative scores .CONCLUSION: This index is discriminative of minimal and significant overall liver disease in a majority of chronic hepatitis C patients and can help in clinical de-cision making.