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目前市售的萘啶酸、吡嘧酸(Piromidic acid),吡卟酸虽对革兰氏阴性菌有较好的抗菌作用,但对革兰氏阳性菌则无抗菌作用。而近年来研究成功的新抗菌剂,不仅对革兰氏阴性菌而且对革兰氏阳性菌也有良好的抗菌作用,既能用于尿路感染又能用于其它疾病的治疗。其中以杏林制药株式会社研制成功的AM-715为一优良的抗菌剂,其化学名为1-乙基_6_氟_1,4-氢_4_氧代_7_(1_哌嗪基)_3_喹啉羧酸。本品对革兰氏阳性菌、阴性菌均有广谱的抗菌作用,其抗菌作用比萘啶酸、吡卟酸及Miloxacin为好。其最低抑菌浓度对葡萄球菌属为0.39～1.56μg/ml,链球菌属为1.56～3.13μg/ml,大肠杆菌为
At present, Nalidixic acid, Piromidic acid and Pyrazin have good antibacterial activity against Gram-negative bacteria, but no antibacterial activity against Gram-positive bacteria. In recent years, successful research new antibacterial agents, not only for Gram-negative bacteria but also for Gram-positive bacteria also have good antibacterial activity, both for urinary tract infection can also be used for the treatment of other diseases. Among them, AM-715 successfully developed by Xinglin Pharmaceutical Co., Ltd. is an excellent antibacterial agent whose chemical name is 1-ethyl-6-fluoro-1,4-hydrogen-4-oxo-7- ) _3_ quinoline carboxylic acid. The product of Gram-positive bacteria, negative bacteria have a broad spectrum of antibacterial activity, the antibacterial activity than nalidixic acid, pyrazin and Miloxacin is better. The minimum inhibitory concentration of Staphylococcus is 0.39 ~ 1.56μg / ml, Streptococcus is 1.56 ~ 3.13μg / ml, Escherichia coli is