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在各种胚胎蛋白中,甲胎蛋白最引起大家注意,因为它与原发性肝细胞癌和胚胎性癌有关。1972年作者曾报告在印度儿童期肝硬化患者中,甲胎蛋白的阳性率为45％。另外有人报告,原发性肝癌和印度儿童期肝硬化时,乙型肝炎抗原(HBAg)的阳性率都是很高的。因此,有人设想病毒性肝炎可能系癌变或肝硬化的前驱。无论是肝癌或肝硬化时,人们曾发现HBAg和甲胎蛋白二者之间有显著的密切关系。本文作者在24名新生儿肝炎病人中,检查HBAg和甲胎蛋白观察其相互关系。
Among various embryonic proteins, alpha-fetoprotein has drawn the most attention as it is associated with primary hepatocellular carcinoma and embryonal carcinoma. In 1972, the authors reported a 45% positive rate of alpha-fetoprotein in children with childhood cirrhosis in India. In addition, it was also reported that the positive rate of hepatitis B antigen (HBAg) was high in primary liver cancer and childhood cirrhosis in India. Therefore, it is envisioned that viral hepatitis may be a precursor of carcinogenesis or cirrhosis. When it comes to liver cancer or cirrhosis, it has been found that there is a significant close relationship between HBAg and alpha-fetoprotein. The authors examined the relationship between HBAg and alpha-fetoprotein in 24 neonatal hepatitis patients.