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目的 了解严重急性呼吸综合征(SARS)患者康复后一年内血清中 SARS冠状病毒(SARS-CoV)特异性抗体 IgG的产生水平及动态变化。方法 SARS患者康复后,每隔2-4周抽取IgG抗体阳性的SARS康复期患者血液,经病毒灭活后分离血清,用酶联免疫吸附试验检测 SARS-CoV特异性抗体 IgG;利用Stata 7.0统计学软件对各月份的检测结果进行分析。结果 各康复期患者的各次检测结果均为阳性,出院后约 35 天时抗体平均水平最高。一年内, IgG抗体平均水平呈逐渐下降趋势,下降幅度约为35.8%。结论 SARS康复期患者康复后短期内具有较高水平的 IgG抗体,但随着康复时间的推移,该抗体呈逐渐下降趋势。提示应对该抗体进行长期监测,直至该抗体消失。
Objective To investigate the level of SARS-CoV-specific IgG in serum of patients with severe acute respiratory syndrome (SARS) within one year after rehabilitation. Methods After SARS patients recovered, the blood of SARS convalescent patients with IgG antibody positive was collected every 2-4 weeks. The virus was isolated and the serum was separated. The SARS-CoV specific IgG was detected by enzyme-linked immunosorbent assay. Stata 7.0 Learning software to test the results of each month analysis. Results All convalescence tests showed positive results and the average antibody level was about 35 days after discharge. Within one year, the average level of IgG antibody showed a gradual downward trend, with a decrease of about 35.8%. Conclusions SARS convalescent patients have a higher level of IgG antibodies in the short term after recovery, but the antibody gradually decreases with the recovery time. This antibody should be monitored for long-term monitoring until the antibody disappears.