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为进一步探讨蠲痹合剂治疗膝关节骨性关节炎的作用机理 ,采用Hulth法将新西兰兔造成骨性关节炎模型 ,并随机分为正常组、模型组、中药 (蠲痹合剂 )组和西药 (维骨力 )组 ,6周后通过检测血清及心肝肾组织匀浆中SOD、NO含量 ,X线摄片 ,大体标本观察 ,及关节软骨、滑膜光镜和 /或电镜观察其病理变化。结果显示 ,中药组动物SOD活性显著高于模型组及西药组 ,而关节软骨破坏程度及滑膜组织损伤程度明显低于模型组、西药组 ,NO检测无差异。表明蠲痹合剂能提高SOD含量 ,抑制氧自由基对软骨细胞及基质的损害 ,从而起到防止并延缓关节软骨的退行性改变 ,抑制滑膜炎症的作用
In order to further explore the mechanism of the treatment of osteoarthritis of the knee by Qijuhe, the Hulth method was used to induce osteoarthritis models in New Zealand rabbits and randomly divided into normal group, model group, traditional Chinese medicine group and western medicine. In the Weiguli group, the levels of SOD and NO in the homogenates of serum, heart, liver and kidney were measured after 6 weeks. X-ray and gross specimens were observed, and the pathological changes were observed with articular cartilage, synovial light and/or electron microscope. The results showed that the activity of SOD in the Chinese herb group was significantly higher than that in the model group and the western medicine group, and the degree of articular cartilage destruction and synovial tissue damage were significantly lower than those in the model group and the western medicine group, and there was no difference in NO detection. It is shown that chelating agent can increase the SOD content, inhibit the damage of oxygen free radicals on chondrocytes and stroma, thereby preventing and delaying the degenerative changes of articular cartilage and inhibiting the inflammation of the synovial membrane.