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本文报道实验性大白鼠口服敌敌畏、呋喃丹急性中毒后,用组织化学观察各组织中乙酰胆碱酯酶(AchE)含量的变化,结果:(1)在敌敌畏中毒组中,空肠肠壁神经丛及大脑豆状核内AchE 含量明显减少,肋间肌的运动神经终板区的 AchE 轻度减少,腹腔神经节内 AchE 减少不明显。(2)在呋喃丹中毒组中,以上4种组织内 AchE 均未见减少。(3)提取大白鼠中毒死后的胃液和血液对正常大白鼠的4种靶组织(空肠、大脑、肋间肌、腹腔神经节),进行体外抑制试验结果,空肠和大脑的 AchE 活性对这2种药物最敏感,肋间肌其次,腹腔神经节不敏感。
This article reports the experimental rats oral administration of dichlorvos, carbofuran acute poisoning, the histochemical observation of changes in the content of acetylcholinesterase (AchE), the results: (1) in the dichlorvos poisoning group, jejunum intestinal plexus and brain The content of AchE in the lentiform nucleus decreased significantly, AchE in the motor nerve endplate of the intercostal muscle decreased slightly, and the decrease of AchE in the celiac ganglion was not obvious. (2) In the carbofuran poisoning group, none of the above four tissues showed any decrease in AchE. (3) Gastric fluid and blood after poisoning of rats were tested in vitro for four target tissues (jejunum, brain, intercostal muscle and celiac ganglion) in normal rats, and the results showed that the AchE activity of jejunum and brain The two drugs are the most sensitive, followed by intercostal muscles, celiac ganglia are not sensitive.