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目的：观察药物水飞蓟宾对分离的成年大鼠心肌细胞钙通道阻滞效应。方法：用成年大鼠分离的心肌细胞，以放射性同位素４５Ｃａ２＋作示踪，通过对经细胞膜Ｃａ２＋流入测定，研究药物水飞蓟宾对钙通道的抑制效应，并与钙通道阻滞剂维拉帕米对照。结果：维拉帕米组Ｃａ２＋流入的平均抑制效应为３０％左右（Ｐ＜０．００１），水飞蓟宾组为３６．５０％左右（Ｐ＜０．００１）。结论：药物水飞蓟宾能显著阻滞分离的成年大鼠心肌细胞胞膜钙通道
OBJECTIVE: To observe the effect of silybin on the calcium channel blockade of isolated adult rat cardiomyocytes. METHODS: Myocardial cells isolated from adult rats were traced with radioactive isotope 45Ca2+, and the inhibitory effect of silybin on calcium channels was studied by measuring Ca2+ influx through the cell membrane, and the calcium channel blocker Verapa Meter control. Results: The average inhibitory effect of Ca2+ influx in verapamil group was about 30% (P<0.001), and 36.50% in Silibinin group (P<0.001). CONCLUSION: The drug silybin can significantly block the membrane calcium channels of isolated adult rat cardiomyocytes.