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目的 探讨白细胞介素 - 8(IL - 8)、白细胞介素 - 6 (IL - 6 )在分娩发动中的作用。方法 随机选择孕38～ 41周的 5 4例胎膜完整的单胎初产妇临产前后共 6 0份血清样本 ,进行IL - 8、IL - 6水平测定并分组进行对比分析。结果 妊娠晚期 ,随着孕周的增加 ,血清IL - 8水平逐渐增高 ,宫颈逐渐变软展平。IL - 8水平与宫颈Bish op评分呈直线正相关 (r =0 76 3,P <0 0 0 1)。临产后血清IL - 8水平明显低于临产水平 (P <0 0 5 ) ,且在第一产程各阶段差异显著 (F =11 32 ,P <0 0 1)。随着产程进展 ,IL - 8水平逐渐下降。临产前血清IL - 6水平较低 ,分娩发动后显著升高 (t =10 0 3,P <0 0 0 1) ,并随宫缩增强逐渐升高。结论 IL - 8是引起宫颈成熟的关键因素之一 ,在启动分娩的准备或激活阶段起主导作用 ,而IL - 6则可能参与分娩的维持与加速。
Objective To investigate the role of interleukin - 8 (IL - 8) and interleukin - 6 (IL - 6) in labor onset. Methods Sixty serum samples of 54 singletonic primiparous women with prenatal and postpartum pregnancies were randomly selected from 38 to 41 weeks of gestation. The levels of IL - 8 and IL - 6 were measured and compared in groups. Results In the third trimester of pregnancy, with the increase of gestational age, the level of serum IL - 8 gradually increased, and the cervix gradually softened and flattened. The level of IL - 8 was positively correlated with cervical Bishop score (r = 0 763, P <0.01). The serum level of IL - 8 after labor was significantly lower than that of labor (P <0.05), and there was a significant difference in all stages of the first stage of labor (F = 11 32, P 0 01). As labor progresses, the level of IL - 8 declines gradually. The level of IL - 6 in prenatal serum was lower, the level of IL - 6 was significantly higher after labor onset (t = 10 0 3, P 0 01), and increased gradually with the increase of contractions. Conclusions IL - 8 is one of the key factors leading to cervical ripening, which plays a leading role in the initiation or activation of childbirth. However, IL - 6 may be involved in the maintenance and acceleration of childbirth.