论文部分内容阅读
可诱导共刺激分子(ICOS)及其配体ICOSL是CD28/B7家族的成员,它所提供的共刺激信号可以为T细胞提供活化所需要的第2信号。ICOS与ICOSL通路的主要功能为增强记忆反应、增殖反应、调控效应T细胞的活化和改变Th1/Th2细胞亚群分化及细胞因子分泌;影响B细胞抗体的分泌。近年来研究显示多种自身免疫性疾病与ICOS/ICOSL途径相关,包括该途径直接参与Behcet病、多发性肌炎等多种自身免疫性疾病的发病机制;作为评估自身免疫性疾病活动度的血清学指标或治疗疗效的生物学标志。提示干扰该途径可为治疗自身免疫性疾病提供新的策略。
Inducible costimulatory molecule (ICOS) and its ligand ICOSL, a member of the CD28 / B7 family, provide co-stimulatory signals that provide T cells with the second signal required for activation. The main function of ICOS and ICOSL pathway is to enhance memory reaction, proliferation reaction, regulate the activation of effector T cells and change the differentiation of Th1 / Th2 cell subsets and cytokines; affect the secretion of B cell antibodies. In recent years, studies have shown that a variety of autoimmune diseases are associated with the ICOS / ICOSL pathway, including the pathogenesis of this pathway that is directly involved in a number of autoimmune diseases, such as Behcet’s disease, polymyositis; as a measure of autoimmune disease activity Biological indicators of biological indicators or therapeutic efficacy. Tip Interference with this pathway may provide a new strategy for the treatment of autoimmune diseases.