论文部分内容阅读
研究药物体内代谢过程都要涉及药物的分离、定性和定量,以往多采用化学方法进行检测分析,但对其样品的处理要求高、操作繁琐、灵敏度低、有时尚难满足实验要求;也有利用高速液相色谱、色谱-质谱联用技术对药物进行分析,操作虽然简单了一些,但仍有对样品处理要求较高的问题。如此,我们设想采用双标记药物后,测定两种放射性核素强度的 研究药物体内代谢过程都要涉及药物的分离、定性和定量,以往多采用化学方法进行检测分析,但对其样品的处理要求高、操作繁琐、灵敏度低、有时尚难满足实验要求;也有利用高速液相色谱、色谱-质谱联用技术对药物进行分析,操作虽然简单了一些,但仍有对样品处理要求较高的问题。如此,我们设想采用双标记药物后,测定两种放射性核素强度的
Research drug metabolism in the body must involve the separation of drugs, qualitative and quantitative analysis, the past, the use of chemical methods for detection and analysis, but its sample processing requirements, cumbersome operation, low sensitivity, fashion difficult to meet the experimental requirements; also use high-speed Liquid Chromatography, Chromatography - Mass Spectrometry Analysis of drugs, although the operation is a bit simple, but there are still high sample processing problems. Thus, we envisaged the use of dual-labeled drugs, the determination of the strength of the two radionuclides of the drug metabolism in the body must involve the separation, qualitative and quantitative drugs, the past, the use of chemical methods for detection and analysis, but the sample processing requirements High, cumbersome operation, low sensitivity, fashion difficult to meet the experimental requirements; there are also the use of high-speed liquid chromatography, chromatography - mass spectrometry for the analysis of drugs, the operation is simpler, but there are still high sample processing problems . Thus, we envisaged the determination of the intensity of both radionuclides after the use of double-labeled drugs