闭锁综合征(Locked-in syndrome)是临床少见的一种特殊类型的意识障碍。临床表现意识清醒,缄默不语,四肢不同程度瘫痪,仅均以睁闭眼表示“是”或“否”。如不熟悉此病,常被误诊为昏迷。现将我科收治的5例并结合文献复习。例1 男,59岁。入院前3天午睡醒来突感头晕,说话不清,频频呃逆。次日吞咽困难,饮食发呛,肢体力弱。既往血压高20余年。查体:血压 Locked-in syndrome is a rare clinical type of disturbance of consciousness. Clinical manifestations of conscious, silent, limbs paralyzed to varying degrees, only with open eyes said “yes” or “no.” If not familiar with the disease, often misdiagnosed as coma. Now we receive 5 cases and review the literature. Example 1 male, 59 years old. 3 days before admission nap wake up suddenly felt dizzy, speechless, frequent hiccups. The next day dysphagia, diet choke, physical weakness. Past high blood pressure more than 20 years. Physical examination: blood pressure