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目的 :采用醋酸洗必泰和甲硝唑制备一种性质稳定、刺激性小的滴眼剂。方法 :选用 2 .6%甘油做渗透压调整剂 ,以系数倍率法用于滴眼剂两主药的含量测定和制剂稳定性考察 ,进行临床疗效观察并用润舒滴眼液做对照。结果 :2 .6%甘油做渗透压调整剂时刺激性很小 ,醋酸洗必泰和甲硝唑的加样回收率分别为 99.3 7% (RSD =0 .2 2 % )和10 0 .6% (RSD =0 .5 9% ) ,对急性卡他性结膜炎的总有效率为 10 0 % ,慢性卡他性结膜炎的总有效率为 95 % ,有效率明显优于润舒滴眼液。结论 :该滴眼液配方合理 ,性质稳定 ,疗效可靠 ,刺激性小。
Objective: The use of chlorhexidine acetate and metronidazole to prepare a stable, less irritating eye drops. Methods: The osmotic pressure regulator was selected with 2.6% glycerol, and the method of coefficient multiplication was used to determine the content of two main drugs and the stability of preparation. The clinical curative effect was observed and compared with Runshu Eye Drops. Results: When 2.6% glycerol was used as the osmotic regulator, the irritation was very small. The recoveries of chlorhexidine acetate and metronidazole were 99.37% (RSD = 0.222%) and 100.6% (RSD = 0.59%), the total effective rate of acute catarrhal conjunctivitis was 100%, the total effective rate of chronic catarrhal conjunctivitis was 95%, the effective rate was significantly better than Runshu eye drops . Conclusion: The eye drops formula is reasonable, stable in nature, reliable, less irritating.