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采用放射免疫法测定40例新生儿缺氧缺血性脑病(HIE)患儿的血浆肾素(PRA)、血管紧张素Ⅱ(PAⅡ)、醛固酮(PALD)水平。结果显示:PRA无明显变化,急性期轻度HIE的PAⅡ(201.34±51.38Pg/ml)、PALD(0.362±0.107)与中重度HIE的PAⅡ(362.34±75.15Pg/ml)、PALD(0.543±0.152ng/ml)比较,均有显著差异(t=2.813,P<0.05;t=3.101,P<0.05),并且PAⅡ,PALD均与1分钟Apgar评分呈显著负相关(r=0.554,P<0.05;r=-0.561,P<0.05)提示HIE时肾素-血管紧张素-醛固酮系统参与并加重了该病的发生。恢复期HIE的PAⅡ、PALD与正常对照组比较无显著差异(t=0.584,P>0.05;t=0.312,P>0.05),故可用来作病情恢复的指标之一。
The levels of plasma renin (PRA), angiotensin Ⅱ (PA Ⅱ) and aldosterone (PALD) in 40 neonates with hypoxic-ischemic encephalopathy (HIE) were measured by radioimmunoassay. The results showed that there was no significant change in PRA. PAⅡ (201.34 ± 51.38Pg / ml), PALD (0.362 ± 0.107) and PAⅡ (362.34 ± 75.15Pg / ml) and PALD (0.543 ± 0.152 (t = 2.813, P <0.05; t = 3.101, P <0.05). There was a significant negative correlation between PAⅡ and PALD and Apgar score at 1 minute (r = 0.554, P <0.05) ; r = -0.561, P <0.05) suggested that the renin-angiotensin-aldosterone system participated and aggravated the occurrence of HIE. PAII and PALD in convalescent HIE had no significant difference with normal control group (t = 0.584, P> 0.05; t = 0.312, P> 0.05).