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目的:观察丹参酮ⅡA对兔心肌梗死再灌注后无复流的影响,并探讨其作用机制。方法:新西兰大白兔40只,随机分成生理盐水灌注对照组(Ⅰ)、丹参酮再灌注治疗组(Ⅱ)、冠脉结扎前丹参酮治疗组(Ⅲ)、假手术组(Ⅳ),每组10只。制备急性心肌梗死再灌注模型。再灌注后观察左心室心肌梗死程度、无复流程度及ST段抬高指数。结果:①与Ⅰ组相比,Ⅱ组、Ⅲ组的梗死面积及无复流面积均较小(P<0.05),而Ⅱ组及Ⅲ组之间无明显差异(P>0.05)。②Ⅰ组、Ⅱ组及Ⅲ组组结扎前ST段抬高指数无明显差异(P>0.05),再灌注后Ⅱ组、Ⅲ组ST段抬高指数均小于Ⅰ组的(P<0.05),而Ⅱ组及Ⅲ组之间无明显差异(P>0.0)。结论:丹参酮ⅡA磺酸钠注射液能减小心肌梗死面积、减轻无复流的发生,减轻心肌损伤。
Objective: To observe the effect of tanshinone Ⅱ A on no-reflow after myocardial infarction reperfusion in rabbits and to explore its mechanism. Methods: Forty New Zealand white rabbits were randomly divided into three groups: normal saline group (Ⅰ), tanshinone group (Ⅱ), tanshinone group (Ⅲ) and sham operation group . Preparation of acute myocardial infarction reperfusion model. After reperfusion, the extent of left ventricular myocardial infarction, no-reflow degree and ST-segment elevation index were observed. Results: ①Compared with group Ⅰ, infarction area and no-reflow area in group Ⅱ and group Ⅲ were smaller (P <0.05), while there was no significant difference between group Ⅱ and group Ⅲ (P> 0.05). ② There was no significant difference in ST elevation index in group Ⅰ, group Ⅱ and group Ⅲ before operation (P> 0.05). After reperfusion, ST segment elevation index in group Ⅱ and group Ⅲ was less than that of group Ⅰ (P <0.05) There was no significant difference between group Ⅱ and group Ⅲ (P> 0.0). Conclusion: Tanshinone Ⅱ A sodium sulfonate injection can reduce myocardial infarction area, reduce the occurrence of no-reflow, reduce myocardial injury.