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肌肉注射是一种最常用的和方便的肠外给药方法。但作者从综述其他作者临床经验和观察指出,有些药物肌肉注射后吸收缓慢、不规则或不完全,即生物利用度较低。这些药物肌肉注射的效果在某些情况下可能反不及同等剂量口服者。生物利用度(Bioavailability)是指药物吸收的程度和时间。作者在本文中着重讨论了安定、利眠宁、苯妥英钠、地高辛和利多卡因五种药物肌肉注射后的生物利用度,并指出以下三个方面是影响药物肌肉往射生物利用度的主要因素:(1)药物的水溶性:作者认为这是影响药物肌肉
Intramuscular injection is one of the most commonly used and convenient parenteral methods. However, from the review of other authors’ clinical experience and observation, the authors point out that some drugs absorb slowly, irregularly or incompletely after intramuscular injection, ie, have low bioavailability. The effect of intramuscular injections of these drugs may in some cases be counter-optimal to the equivalent dose of oral. Bioavailability refers to the extent and timing of drug absorption. In this paper, the author focuses on the bioavailability of five drugs, diazepam, phenytoin sodium, digoxin and lidocaine, after intramuscular injection. The following three aspects are pointed out that the following three aspects affect the bioavailability The main factors: (1) the water-solubility of drugs: the authors think this is the impact of drug muscle