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应用ELISA法,检测0.5岁～1岁组328例肺炎和364例毛细支气管炎(毛支)患儿患病极期IFN-α、IL-2、IL-4的含量。结果表明:肺炎组血清IFN-α、IL-2和IL-4含量分别为501.2ng/L±97.6ng/L、316.8ng/L±86.2ng/L和18.2ng/L±11.4ng/L。其IFN-α,IL-2含量均高于同龄对照组,IL-4含量低于同龄对照组,t值分别为15.8、9.80、8.90,P<0.001。毛支组血清IFN-α,IL-2和IL-4含量分别为238.0ng/L±102.4ng/L、89.6ng/L±29.8ng/L和84.6ng/L±37.2ng/L,其IFN-α,IL-2的含量低于同龄对照组,IL-4的含量高于同龄对照组,t值分别为6.70、13.5和17.6,P<0.001。肺炎,毛支患儿血清中IFN-α与IL-4亦呈负相关(r_1=-0.54、r_2=-0.68,P<0.01)。说明,IFN-α与IL-4这对拮抗因子在两种疾病中呈异常比值关系,可作为判断感染或过敏的一项指标,为临床提供治疗依据。
The serum levels of IFN-α, IL-2 and IL-4 in 328 patients with pneumonia and 364 patients with bronchiolitis (bronchiolitis) from 0.5 to 1 year old were detected by ELISA. The results showed that the levels of IFN-α, IL-2 and IL-4 in pneumonia group were 501.2ng / L ± 97.6ng / L, 316.8ng / L ± 86.2ng / L and 18.2ng / L ± 11.4ng / L, respectively. The levels of IFN-α and IL-2 were higher than the same age control group, IL-4 content was lower than the same age control group, t values were 15.8,9.80,8.90, P <0.001. The contents of IFN-α, IL-2 and IL-4 in the branch of hair were 238.0ng / L ± 102.4ng / L, 89.6ng / L ± 29.8ng / L and 84.6ng / L ± 37.2ng / L, The levels of IL-4 and IL-4 were lower than those in the same age group, and the levels of IL-4 were higher than the control group of the same age with t values of 6.70, 13.5 and 17.6, respectively, P <0.001. The levels of IFN-α and IL-4 in children with pneumonia and bronchiolitis were also negatively correlated (r_1 = -0.54, r_2 = -0.68, P <0.01). This indicates that the antagonistic factors of IFN-α and IL-4 have an abnormal ratio between the two diseases and can be used as an index to judge the infection or allergy and provide the basis for clinical treatment.