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按照处方的功能主治,采用4种炎症模型和2种镇痛模型,研究了舒督丹的抗炎镇痛作用。结果发现10、20、40g生药/kgig给药,对小鼠腹腔毛细血管通透性和巴豆油性耳肿的抑制作用非常显著,对大鼠角叉菜胶足肿和佐剂关节炎的抗炎作用也非常显著。既能提高大鼠和小鼠对温热刺激的痛阈值,又能减少小鼠对化学刺激的扭体次数,其镇痛作用具有起效快和作用时间长的特点。为该药在临床上治疗强直性脊柱炎、类风湿关节炎等提供了实验依据。
In accordance with the function of the prescription, four kinds of inflammation models and two kinds of analgesia models were used to study the anti-inflammatory and analgesic effects of Shu Du Dan. The results showed that 10, 20, and 40 g crude drug/kgig administration had a significant inhibitory effect on abdominal capillary vascular permeability and croton oily ear swelling, and its anti-inflammatory effect on rat carrageenan foot swelling and adjuvant arthritis It is also very significant. It can not only increase the pain threshold of rats and mice for warm stimulation, but also reduce the number of writhing mice with chemical stimulation. Its analgesic effect has the characteristics of quick onset and long duration of action. For the drug in the clinical treatment of ankylosing spondylitis, rheumatoid arthritis and other experimental basis.