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目的 :探讨老年缺血性脑血管病血瘀证患者的红细胞变形性及一氧化氮 ( NO)水平的变化。方法 :检测 5 5例老年缺血性脑血管病血瘀证患者的红细胞变形指数和 NO的水平。其中短暂性脑缺血发作 ( TIA) 2 5例 ,脑梗死 3 0例 ;另设 2 6例正常对照组作对比观察。结果 :血瘀证 TIA患者红细胞变形指数 ( 0 .4 67± 0 .14 5 )显著低于正常对照组 ( 0 .5 0 8± 0 .14 1) ,P<0 .0 5 ,脑梗死患者红细胞变形指数 ( 0 .4 43± 0 .15 6)降低更为明显( P<0 .0 1) ;NO水平 ,TIA患者与正常对照组比较无显著性差异 ( 79.10± 15 .3 7比 76.70± 17.10 ) ,而脑梗死患者 ( 88.5 0± 13 .68)显著升高。结论 :红细胞变形性改变及 NO水平升高在一定程度上均参与了老年缺血性脑血管病血瘀证的发生发展
Objective: To investigate the changes of erythrocyte deformability and nitric oxide (NO) in elderly patients with blood stasis syndrome of ischemic cerebrovascular disease. Methods: Erythrocyte deformability index and NO level were measured in 55 cases of elderly patients with blood stasis syndrome of ischemic cerebrovascular disease. Among them, 25 cases were transient ischemic attack (TIA) and 30 cases cerebral infarction. Another 26 cases of normal control group were compared. Results: The erythrocyte deformability index (0. 4 67 ± 0.14 5) of TIA patients with blood stasis syndrome was significantly lower than that of the control group (0 .5 0 ± 0.14 1), P <0. 05, patients with cerebral infarction The erythrocyte deformability index (0.443 ± 0.156) decreased more significantly (P <0.01). There was no significant difference in NO level between the TIA patients and the normal control group (79.10 ± 15.37 vs. 76.70 ± 17.10), while patients with cerebral infarction (88.5 ± 13.68) were significantly higher. Conclusion: The changes of erythrocyte deformability and the increase of NO level are involved in the occurrence and development of blood stasis syndrome of senile ischemic cerebrovascular disease to a certain extent