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疟疾获得性免疫机理的研究指出,保护性抗体对细胞内原虫无作用,但可阻止裂殖子释放入血浆后的发展。有人观察到免疫血清可凝集游离的裂殖子,并且阻止其附着于易感宿主红细胞的接受点。这说明裂殖子抗原在疟疾特异性免疫中的重要作用。本文报告用裂殖子作疫苗对猴进行免疫接种抗诺氏疟原虫感染的应用。实验用猴为恒河猴(Macaca mulatta)及克拉猴(M.fascicularis)。诺氏疟原虫分W株和Nuri株(N株),又根据裂殖体感染细胞凝集(SICA)试验区分为不同的系别。免疫接
Studies on the mechanisms of acquired immunity in malaria state that protective antibodies have no effect on protozoan cells but prevent the development of merozoites after their release into the plasma. It has been observed that immune sera can agglutinate free merozoites and prevent them from attaching to the site of acceptance of susceptible host erythrocytes. This shows the important role of merozoite antigens in malaria-specific immunity. This article reports the use of meconium as a vaccine for immunization of monkeys against P. nidulans infection. Experimental monkeys are Macaca mulatta and M. fascicularis. Plasmodium Rhodopus strain W and Nuri (strain N) were also divided into different lines according to the SICA test. Immunization