巨噬细胞是一群进化上起源较早的细胞,在漫长的进化过程中被赋予了多种功能。巨噬细胞一般被分为M1和M2型,其中M1型巨噬细胞在宿主抵抗细菌和病毒感染过程中发挥重要作用,具有促进炎症的作用;M2型巨噬细胞则在寄生虫感染、组织损伤修复、肿瘤发生发展过程中发挥重要作用,具有抑制炎症的作用。大阪大学免疫前沿研究中心的Shizuo Akira教授和他的团队发现Tribble假激酶蛋白家族成员Trib1在组织定居M2型巨噬细胞的发育过程中发挥重要作用,这一成果发表在 Macrophages are a group of cells that are evolutionarily older and have been given a variety of functions over long evolutionary cycles. Macrophages are generally divided into M1 and M2 types, M1 macrophages play an important role in the host against bacterial and viral infection, with the role of promoting inflammation; M2 macrophages in parasite infection, tissue damage Repair, tumor development plays an important role in the process of development, with the role of inhibiting inflammation. Professor Shizuo Akira and his team at Osaka University’s Frontiers for Immunosuppressive Research found that Trib1, a member of Tribble’s family of pseudokinase proteins, plays an important role in the development of tissue-resident M2 macrophages and is reported in