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本文对抗疟新药蒿甲醚影响小鼠免疫功能的作用进行了实验研究。结果表明:蒿甲醚对小鼠脾脏T淋巴细胞增殖反应及白细胞介素2(IL—2)活性的作用不明显(P>0.05),但蒿甲醚能使小鼠胸腺重量减少,同时,一定剂量(每千克体重给药100mg、250mg)的蒿甲醚对小鼠脾脏B淋巴细胞增殖反应有抑制作用(P<0.05或P<0.01)。提示:蒿甲醚对细胞免疫功能作用不明显,但对体液免疫功能可能有抑制作用,而且其抑制作用随剂量增大而增强。因而认为,蒿甲醚对免疫系统的作用可能与其能治疗脑型疟的作用机制有关,临床确定合理治疗剂量时应考虑该药对免疫功能的影响。
The effect of artemether, a new anti-malaria drug, on immune function in mice was studied experimentally. The results showed that the effect of artemether on the proliferation of spleen T lymphocytes and the activity of interleukin-2 (IL-2) was not significant (P>0.05), but artemether can reduce the weight of thymus in mice. A certain dose (100 mg, 250 mg per kg body weight) of artemether inhibited the proliferation of spleen B lymphocytes in mice (P<0.05 or P<0.01). It is suggested that artemether has no obvious effect on cellular immune function, but it may have inhibitory effect on humoral immune function, and its inhibitory effect increases with increasing dose. Therefore, it is believed that the effect of artemether on the immune system may be related to its mechanism of action in the treatment of cerebral malaria, and the influence of the drug on immune function should be considered when determining a reasonable therapeutic dose.