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在试用国产氨噻肟头孢菌素钠治疗急性细菌性感染的过程中,用微生物法和高效液相色谱法(HPLC)研究了在18例患者的体内药动学。 18例患者包括:肝肾功能正常6例,中至重度肾功不全6例。重度肝功不全5例,糖尿病并发金色葡萄球菌感染、酮症昏迷,感染性休克1例。
In trials of domestic cefotaxime sodium for the treatment of acute bacterial infections, in vivo pharmacokinetics was studied in 18 patients by microbiological and high performance liquid chromatography (HPLC). Eighteen patients included six patients with normal liver and kidney function and six patients with moderate to severe renal insufficiency. Severe hepatic insufficiency in 5 cases, diabetes complicated with Staphylococcus aureus infection, ketosis coma, septic shock in 1 case.