Using the GPS velocity data from 27 stations around the Eastern Kunlun fault as constraints,we first invert the slip velocities of the Eastern Kunlun fault,the north boundary fault of the Qaidam basin,the Mani-Yushu fault and the Margai Caka fault before the Kekexili MS8.1 earthquake with a 3-D elastic half-space dislocation model. The deformation field calculated from the slip movement of these faults can be considered the deformation background field of the earthquake. Based on the deformation background field with tectonic implications,we have obtained the strain field and earthquake moment accumulation field. The results show that there are two obvious high moment accumulation rate regions,one of which is the Dongdatan-Xidatan segment of the Eastern Kunlun fault where the M_S8.1 earthquake occurred in 2001. Using the GPS velocity data from 27 stations around the Eastern Kunlun fault as constraints, we first invert the slip velocities of the Eastern Kunlun fault, the north boundary fault of the Qaidam basin, the Mani-Yushu fault and the Margai Caka fault before the Kekexili MS8.1 earthquake with a 3-D elastic half-space dislocation model. The deformation field calculated from the slip movement of these faults can be considered the deformation background field of the earthquake. Based on the deformation background field with tectonic implications, we have obtained the strain field and earthquake moment accumulation field. The results show that there are two obvious high moment accumulation rate regions, one of which is the Dongdatan-Xidatan segment of the Eastern Kunlun fault where the M_S8.1 victim occurred in 2001.