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６３例重症病毒性脑炎分别用纯化白细胞ａ干扰素１００万ｕ／ｄ，１０万ｕ／ｄ，５万ｕ／ｄ，２万ｕ／ｄ及对照组治疗。治疗组共５６例，对照组８例。临床观察结果表明，治疗组各组治愈率，治疗时间及各项症状、体征平均消失时间均比对照组明显缩短，差异有显著意义或非常显著意义。每日１００万ｕ于扰素组治愈率为１００％；１０万ｕ／ｄ干扰素治疗组治愈率为９５．２％，好转率为４．８％；５万ｕ／ｄ治疗组治愈率为８９．０％，好转率为５．５％，无效率为５．５％；２万ｕ／ｄ治疗组治愈率为８３．４％，好转率为８．３％，无效率为８．３％；未经干扰素治疗组治愈率为７２．７％，好转率为１８．３％，无效率为９％。我们体会；１０万ｕ～１００万ｕ／ｄ白细胞ａ干扰素治疗重症病毒性脑炎具有显著疗效，对于控制病毒感染，保护脑组织及防止后遗症的发生具有重要意义，在治疗中，未发现ａ－干扰素有毒副反应。
Sixty-three patients with severe viral encephalitis were treated with purified leukocyte interferon-alpha 1 million u / d, 100000u / d, 50000u / d, 20000u / d and control group respectively. A total of 56 cases in the treatment group and 8 cases in the control group. The results of clinical observation showed that the cure rate, the treatment time, the symptoms and the average disappearance time of the signs in the treatment group were significantly shorter than those in the control group, and the difference was significant or very significant. The daily cure rate of 100 million u in the interferon group was 100%; the cure rate of the 10 million u / d interferon group was 95.2% and the improvement rate was 4.8%; the cure rate in the 50000u / d treatment group was 89.0%, the improvement rate was 5.5% and the inefficiency rate was 5.5%. The cure rate of 20 000 u / d treatment group was 83.4%, the improvement rate was 8.3% and the inefficiency rate was 8.3% %; The non-interferon treatment group cure rate was 72.7%, the improvement rate was 18.3%, the inefficiency was 9%. We know; 100000 u to 1 million u / d leukocyte a interferon treatment of severe viral encephalitis has a significant effect, for the control of viral infection, protect brain tissue and prevent the occurrence of sequelae is of great significance in the treatment, did not find a Interferon toxic side effects.