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目的了解荆州地区近年来婴幼儿人巨细胞病毒(HCMV)感染的发生率及特点,为预防和治疗HCMV提供信息。方法对2010年1月-2014年8月荆州市第一医院的1 568例0~3周岁婴幼儿的资料进行回顾性分析。按年龄分为<28天组、28天~6个月组、6~12个月组、1~3年组,分析HCMV血清学结果和相关临床资料以及不同季节的婴幼儿HCMV感染率。HCMV感染率的判断基于Ig G和Ig M的血清学结果。结果 2010年1月-2014年8月荆州地区婴幼儿HCMV Ig G和Ig M总感染率为88.90%(1 394/1 568),不同年龄组婴幼儿近期HCMV感染率分别为6.98%、21.05%、28.57%和24.00%,组间比较差异有统计学意义(P<0.05)。不同季节婴幼儿HCMV新发感染率比较差异无统计学意义(χ2=1.826,P=0.609)。结论 3岁前婴幼儿是HCMV的易感人群,早期采取防控措施很有必要。
Objective To understand the incidence and characteristics of infant cytomegalovirus (HCMV) infection in Jingzhou area in recent years and provide information for the prevention and treatment of HCMV. Methods The data of 1 568 infants aged 0-3 years old from the First Hospital of Jingzhou from January 2010 to August 2014 were analyzed retrospectively. The patients were divided into two groups according to their age: <28 days, 28 days to 6 months, 6 to 12 months, and 1 to 3 years. Serum HCMV seroprevalence and related clinical data were analyzed, and HCMV infection rates in different seasons were analyzed. The judgment of HCMV infection rate is based on the serological results of Ig G and Ig M. Results The total infection rate of IgM and IgM of HCMV among infants and young children in Jingzhou was 88.90% (1 394/1 568) from January 2010 to August 2014. The infection rates of HCMV among infants and young children in different age groups were 6.98% and 21.05% , 28.57% and 24.00% respectively. There was significant difference between the two groups (P <0.05). There was no significant difference in the new infection rates of HCMV between infants and young children in different seasons (χ2 = 1.826, P = 0.609). Conclusion Infants and children of 3 years old are susceptible to HCMV. Early prevention and control measures are necessary.