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目的 :探讨血清可溶性白细胞介素 - 2受体测定对消化系肿瘤的诊断价值。方法 :采用酶联免疫法测定 5 6例消化系肿瘤患者和 40例健康人血清可溶性白细胞介素 - 2受体 (SIL - 2R)。结果 :肿瘤患者血清SIL- 2R水平显著高于正常人 ,分别为 (110 0± 380 )× 10 3U L和 (480± 34 0 )× 10 3U L(P <0 0 5 )。 14例胃癌患者胃大部分切除术后 ,血清SIL - 2R水平显著下降 [术前 (10 80± 40 0 )× 10 3U L和术后 (6 80± 40 0 )× 10 3U L ,P <0 0 5 ]。以SIL - 2R780× 10 3U L为截断值 ,其诊断肿瘤的敏感性为 85 % ,特异性为 75 %。结论 :SIL - 2R的测定有助于消化系肿瘤的诊断、疗效观察、预后判定 ,并可作为一种新的胃癌生物学标记。
Objective: To explore the diagnostic value of serum soluble interleukin-2 receptor in digestive system tumors. Methods: Serum soluble interleukin-2 receptor (SIL-2R) was determined by enzyme-linked immunosorbent assay in 56 patients with digestive system tumors and 40 healthy subjects. Results: Serum SIL-2R levels in tumor patients were significantly higher than those in normal controls (110 0 ± 380) × 10 3U L and (480 ± 34 0) × 10 3U L, respectively (P <0 05). Serum SIL-2R levels were significantly reduced in 14 patients with gastric cancer after major gastrectomy [10 80 ± 40 0 ×10 3 U L before operation and 6 80 ± 40 0 ×10 3U L after operation,P <0 0 5 ]. With a cutoff of SIL-2R780×10 3U L , the sensitivity for diagnosis of tumors was 85% and specificity was 75%. Conclusion: The determination of SIL-2R is helpful for the diagnosis, curative effect observation and prognosis of digestive tumors, and it can be used as a new biomarker for gastric cancer.