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根据白塞病(BD)国际分类标准,确诊为本病的35例作为研究组,取其口腔、生殖器、皮肤和血管病损组织进行荧光检测。选用复发性阿夫他口炎(RAS)20例作为对照组。结果显示:BD88.6%患者血清中可检测出口腔粘膜的自身抗体,85.7%患者血清中可检测出病损皮肤、血管组织的自身抗体,75%患者血清中可检测出生殖器溃疡部位的自身抗体,前者与RAS比较,P<0.01。由于检测方法不同,本文用间接荧光法阳性结果较高。故用本法检测无疑对BD诊断有一定临床价值。
According to the international classification standard of Behcet’s disease (BD), 35 patients diagnosed as the disease were selected as the research group, and the tissues of oral cavity, genitalia, skin and blood vessels were taken for fluorescence detection. Recurrent aphthous stomatitis (RAS) 20 cases as a control group. The results showed that the oral mucosal autoantibodies could be detected in sera of patients with BD88.6%, the autoantibodies of diseased skin and blood vessels could be detected in the sera of 85.7% of the patients, and the sera of the genital ulcers could be detected in 75% of the patients Antibody, the former compared with RAS, P <0.01. Due to different detection methods, this paper using indirect fluorescence positive results higher. Therefore, the detection of this method undoubtedly has some clinical value of BD diagnosis.