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消除半衰期对于选择治疗血药浓度范围较窄的药物间隔是至关重要的,具有剂量依赖药动学性质的药物,其消除半衰期直接随血药浓度变化而变化.此时,可根据临床经验,找出两个不同血药浓度值和治疗血药浓度值的范围,通过清除或示踪剂量的研究,求出其K_m和V_(max)值,这样可计算治疗血药浓度范围内的消除半衰期,以便得到在治疗时,任何血药浓度时的消除半衰期的值.若已知某一个体的药物代谢酶系统的K_m和V_(max)值,可计算任一稳态血药浓度时消除半衰期公式如下:
Elimination of half-life for the choice of treatment of drug concentration within a narrow range of drug interval is crucial, with dose-dependent pharmacokinetics of the drug, its elimination half-life directly with changes in plasma concentration changes at this time, according to clinical experience, To find the range of values for two different plasma concentrations and therapeutic plasma concentrations, the K_m and Vmax values were calculated by clearance or tracer dose studies to calculate the elimination half-lives within the range of therapeutic plasma concentrations In order to obtain the value of elimination half-life at the time of treatment at any plasma concentration.If the Km and Vmax values of the drug metabolizing enzyme system of an individual are known, the half-life can be calculated at any steady-state plasma concentration The formula is as follows: